Endocrine Abstracts

Background: Nonalcoholic fatty liver disease (NAFLD) is an increasingly recognised disorder with an estimated prevalence of 20–30% in the general population and is considered as the hepatic manifestation of the metabolic syndrome. Fatty liver index (FLI) has been developed as an indicator of hepatic steatosis (HS). Another marker, the lipid accumulation product (LAP) index, initially developed to assess cardiovascular risk, has been recently shown to be a reliable marker ...

Primary aldosteronism is diagnosed with increasing frequency, especially between patients with hypertension. Thus, a reliable screening test is necessary to avoid costly and demanding diagnostic procedures to this population. The aim of the present study is the evaluation of aldosterone to renine ratio (A/R) in the diagnostic algorithm of patients with hypertension with or without adrenal insidentaloma.A total of 115 subjects were studied: 13 patients wi...

Background: Increased prevalence of abnormal aminotransferase levels and/or ultrasonographic evidence of hepatic steatosis have been found in women with polycystic ovary syndrome (PCOS), being more pronounced in overweight and obese patients. However, few data exist concerning the prevalence of PCOS in premenopausal women with nonalcoholic fatty liver disease (NAFLD).Objective: To investigate the presence of PCOS in overweight and obese premenopausal wom...

Glucocorticoid treatment in congenital adrenal hyperplasia (CAH) is a continuous challenge, with even the experienced clinician struggling to strike the right balance between glucocorticoid over- and undertreatment. There is no consensus on monitoring of glucocorticoid therapy in adults with CAH. Some recommend a serum 17-hydroxyprogesterone (17OHP) target range of 12–36 nmol/l prior to glucocorticoid morning dose. Here we investigated the value of serum and urinary stero...

Aim: To measure interstitial cortisol obtained by adipose tissue microdialysis (MD) as well as serum total and free cortisol in 31 mechanically ventilated patients upon sepsis onset (days 1 and 2). MD tissue glucose, pyruvate, lactate, and glycerol were also measured (as markers of altered or disrupted local energy production).Methods: The Acute Physiology and Chronic Health Evaluation (APACHE II) on day 1 and the sequential organ failure assessment (SOF...